Ctse^tm1Kjy
Targeted Allele Detail

Summary

• Symbol: Ctse^tm1Kjy
• Name: cathepsin E; targeted mutation 1, Kenji Yamamoto
• MGI ID: MGI:3625688
• Synonyms: CatE^-
• Gene: Ctse Location: Chr1:131566052-131603245 bp, + strand Genetic Position: Chr1, 57.14 cM, cytoband F
• Alliance: Ctse^tm1Kjy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced a 3.1-kbp sequence of the gene containing exons 1 to 4. RT-PCR analysis did not detect transcript in spleen tissue from homzygous mutant mice. Immunoblot analysis did not detect protein in homozygous mutant spleen. (J:108745)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctse Mutation: 30 strains or lines available

References

• Original: J:108745 Tsukuba T, et al., Association of cathepsin E deficiency with development of atopic dermatitis. J Biochem. 2003 Dec;134(6):893-902
• All: 13 reference(s)