Ucn2^tm1Pbl
Targeted Allele Detail

Summary

• Symbol: Ucn2^tm1Pbl
• Name: urocortin 2; targeted mutation 1, Wylie W Vale
• MGI ID: MGI:3625732
• Synonyms: Ucn-2 KO
• Gene: Ucn2 Location: Chr9:108815231-108816232 bp, + strand Genetic Position: Chr9, 59.63 cM, cytoband F2
• Alliance: Ucn2^tm1Pbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108744
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the coding sequence. RC-PCR analysis did not detect mRNA in brain, skeletal muscle, and skin tissue from homozygous mutant mice. Immunohistochemical studies of frontal sections from brain did not detect protein in the locus ceruleus of homozygous mutant mice. (J:108744, J:116101)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucn2 Mutation: 8 strains or lines available

References

• Original: J:108744 Chen A, et al., Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci. 2006 May 17;26(20):5500-10
• All: 3 reference(s)