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Ucn2tm1Pbl
Targeted Allele Detail
Summary
Symbol: Ucn2tm1Pbl
Name: urocortin 2; targeted mutation 1, Wylie W Vale
MGI ID: MGI:3625732
Synonyms: Ucn-2 KO
Gene: Ucn2  Location: Chr9:108815231-108816232 bp, + strand  Genetic Position: Chr9, 59.63 cM, cytoband F2
Alliance: Ucn2tm1Pbl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108744
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the coding sequence. RC-PCR analysis did not detect mRNA in brain, skeletal muscle, and skin tissue from homozygous mutant mice. Immunohistochemical studies of frontal sections from brain did not detect protein in the locus ceruleus of homozygous mutant mice. (J:108744, J:116101)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucn2 Mutation:  8 strains or lines available
References
Original:  J:108744 Chen A, et al., Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci. 2006 May 17;26(20):5500-10
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory