Nnt^N68K
Chemically induced Allele Detail

Summary

• Symbol: Nnt^N68K
• Name: nicotinamide nucleotide transhydrogenase; N68K
• MGI ID: MGI:3625821
• Gene: Nnt Location: Chr13:119472063-119545793 bp, - strand Genetic Position: Chr13, 67.21 cM, cytoband D2
• Alliance: Nnt^N68K page

Mutation origin

• Strain of Origin: (C3H/HeH x BALB/c)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as a C to A substitution (c.204C>A) in exon 2 that results in a nonconservative missense asparagine to lysine substitution at amino acid 68 of the protein (p.N68K). Western blot analysis demonstrated that expressed protein was present in pancreatic islets of homozygous mice. (J:108421)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nnt Mutation: 64 strains or lines available

References

• Original: J:93069 Quwailid MM, et al., A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome. 2004 Aug;15(8):585-91
• All: 2 reference(s)