Nnt^G745D
Chemically induced Allele Detail

Summary

• Symbol: Nnt^G745D
• Name: nicotinamide nucleotide transhydrogenase; G745D
• MGI ID: MGI:3625823
• Gene: Nnt Location: Chr13:119472063-119545793 bp, - strand Genetic Position: Chr13, 67.21 cM, cytoband D2
• Alliance: Nnt^G745D page

Mutation origin

• Strain of Origin: (C3H/HeH x BALB/c)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as G>A substitution in exon 14, resulting in a nonconservative substitution of glycine by aspartic acid at amino acid 745 (p.G745D; p.G494D in exon 9 in the C57BL/6J strain (which has a 5-exon 251aa deletion)). Western blot analysis demonstrated that expressed protein was present in pancreatic islets of homozygous mice. (J:108421)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nnt Mutation: 64 strains or lines available

References

• Original: J:93069 Quwailid MM, et al., A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome. 2004 Aug;15(8):585-91
• All: 2 reference(s)