Tg(HBB-GH1)420King
Transgene Detail

Summary

• Symbol: Tg(HBB-GH1)420King
• Name: transgene insertion 420, Donna King
• MGI ID: MGI:3625833
• Synonyms: HS-2 + beta-c hGH, Tg420
• Transgene: Tg(HBB-GH1)420King Location: unknown
• Alliance: Tg(HBB-GH1)420King page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HBB-GH1)420King expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GH1 (2688)

  Gh	(MGI:95707)

• Mutation details: The human genomic growth hormone gene, from its transcription initiation site through the 3' untranslated region, was placed under control of the sheep hemoglobin beta^c promoter joined at its 5' end to a 1.9-kb fragment containing the 5' HS-2 element of the human hemoglobin beta locus control region. Radiolabeled human growth hormone antisense RNA detects transcripts in liver and heart (in the latter presumably from pooled blood) of whole-embryo sections and in bone marrow of sectioned adult tibiae. (J:108828)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:108828 Saban J, et al., Erythroid-specific expression of human growth hormone affects bone morphology in transgenic mice. Bone. 1996 Jan;18(1):47-52
• All: 4 reference(s)