Xrcc6^tm1Gcl
Targeted Allele Detail

Summary

• Symbol: Xrcc6^tm1Gcl
• Name: X-ray repair complementing defective repair in Chinese hamster cells 6; targeted mutation 1, Gloria C Li
• MGI ID: MGI:3625858
• Synonyms: Ku70^-
• Gene: Xrcc6 Location: Chr15:81872036-81924286 bp, + strand Genetic Position: Chr15, 38.33 cM, cytoband E-F
• Alliance: Xrcc6^tm1Gcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108657
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 336 bp in exon 2, including the ATG, by homologous recombination. Western blot confirmed absence of protein in mutant ear fibroblasts and embryo fibroblasts. (J:108657)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc6 Mutation: 63 strains or lines available

References

• Original: J:108657 Ouyang H, et al., Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J Exp Med. 1997 Sep 15;186(6):921-9
• All: 7 reference(s)