Rasgrp3^tm1Jstn
Targeted Allele Detail

Summary

• Symbol: Rasgrp3^tm1Jstn
• Name: RAS, guanyl releasing protein 3; targeted mutation 1, James C Stone
• MGI ID: MGI:3625862
• Synonyms: Rasgrp3^-
• Gene: Rasgrp3 Location: Chr17:75742891-75836049 bp, + strand Genetic Position: Chr17, 46.55 cM
• Alliance: Rasgrp3^tm1Jstn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108677
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P3/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2, interrupting the coding sequence downstream of codon 40 in the Ras exchange motif of the catalytic region. (J:108677)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rasgrp3 Mutation: 43 strains or lines available

Notes

ES cell line = NX1.

References

• Original: J:108677 Coughlin JJ, et al., RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol. 2005 Dec 1;175(11):7179-84
• All: 5 reference(s)