Lmr16^STS/A
QTL Variant Detail

Summary

• QTL variant: Lmr16^STS/A
• Name: leishmaniasis resistance 16; STS/A
• MGI ID: MGI:3625872
• QTL: Lmr16 Location: Chr2:167212221-167212356 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 87.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Lmr16 exhibits additive inheritance.

Lmr16 interacts with Lmr18 on chromosome 16. F2 animals homozygous for BALB/cHeA-derived alleles at Lmr18 and homozygous for STS/A-derived alleles at Lmr16 exhibit increased spontaneous spleen cell proliferation. Each locus has minimal individual effect on splenocyte proliferation.

References

• Original: J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• All: 1 reference(s)