Lmr17^CcS20/Dem
QTL Variant Detail

Summary

• QTL variant: Lmr17^CcS20/Dem
• Name: leishmaniasis resistance 17; CcS20/Dem
• MGI ID: MGI:3625874
• QTL: Lmr17 Location: Chr9:37306197-37306370 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 20.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CcS20/Dem

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: STS/A alleles at this locus were associated with increased levels of TNF alpha in serum. Homozygous BALB/c alleles at Lmr24f and homozygous STS/A alleles at Lmr17 (D9Mit2) increase IFN gmma levels. (J:108764)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Lmr17 exhibits additive inheritance.

Lmr17 interacts with Lmr3 on chromosome 5 to influence serum IFN-gamma levels. F2 animals homozygous for BALB/cHeA-derived alleles at Lrm3 and STS/A-derived alleles at Lrm17 exhibit higher serum IFN-gamma concentrations.

References

• Original: J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• All: 1 reference(s)