Lmr19^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Lmr19^BALB/cHeA
• Name: leishmaniasis resistance 19; BALB/cHeA
• MGI ID: MGI:3625877
• QTL: Lmr19 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 45.35 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Lmr19 exhibits additive inheritance.

Lmr19 interacts with Lmr12 on chromosome 16 to influence spontaneous spleen cell proliferation. Homozygosity for BALB/cHeA-derived alleles at Lmr19 and STS/A-derived alleles at Lmr12 confers increased spontaneous spleen cell proliferation. Each locus individually has minimal effect.

References

• Original: J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• All: 1 reference(s)