Il23a^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Il23a^tm1Gdy
• Name: interleukin 23, alpha subunit p19; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:3625894
• Synonyms: IL23^tm1Gdy
• Gene: Il23a Location: Chr10:128132009-128133953 bp, - strand Genetic Position: Chr10, 76.51 cM, cytoband D3
• Alliance: Il23a^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 through exon 3 was replaced with a lacZ gene and floxed neo cassette. The absence of the p19 transcript was confirmed by RT-PCR. (J:139557)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23a Mutation: 27 strains or lines available

References

• Original: J:139557 Becker C, et al., Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006 Sep 1;177(5):2760-4
• All: 4 reference(s)