Yy1^tm2Yshi
Targeted Allele Detail

Summary

• Symbol: Yy1^tm2Yshi
• Name: YY1 transcription factor; targeted mutation 2, Yang Shi
• MGI ID: MGI:3625967
• Synonyms: yy1^flox
• Gene: Yy1 Location: Chr12:108758899-108786074 bp, + strand Genetic Position: Chr12, 59.58 cM
• Alliance: Yy1^tm2Yshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108369
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: Exon 1 and the promoter region were flanked with loxP sites by homologous recombination. An FRT-flanked neomycin cassette was inserted downstream of the 3' loxP site. Protein expression in heterozygotes is reduced by about 25% compared to wild-type mice. (J:108369)

Expression

In Mice Carrying this Mutation:	76 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Yy1 Mutation: 35 strains or lines available

References

• Original: J:108369 Affar el B, et al., Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol. 2006 May;26(9):3565-81
• All: 16 reference(s)