Shox2^tm1Ddu
Targeted Allele Detail

Summary

• Symbol: Shox2^tm1Ddu
• Name: SHOX homeobox 2; targeted mutation 1, Denis Duboule
• MGI ID: MGI:3626291
• Synonyms: Shox2^flox, Shox2^floxed
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^tm1Ddu page

Limb phenotype of Shox2^tm1Ddu/Shox2^tm1.1Ddu Tg(Prrx1-cre)1Cjt mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107668
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the entire coding region of the locus. An FRT-flanked neo included in the vector was removed by FLP mediated recombination. (J:107668)

Disease models

Expression

In Mice Carrying this Mutation:	90 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 20 strains or lines available

References

• Original: J:107668 Cobb J, et al., A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4511-5
• All: 17 reference(s)