Chmp5^tm1Gho
Targeted Allele Detail

Summary

• Symbol: Chmp5^tm1Gho
• Name: charged multivesicular body protein 5; targeted mutation 1, Sankor Ghosh
• MGI ID: MGI:3626293
• Synonyms: Chmp5^-
• Gene: Chmp5 Location: Chr4:40948553-40965302 bp, + strand Genetic Position: Chr4, 20.69 cM
• Alliance: Chmp5^tm1Gho page

Abnormal development of Chmp5^tm1Gho/Chmp5^tm1Gho embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107913
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-7 of the locus were replaced with a neomycin resistance gene. Immunoblot failed to detect protein in mutant cell lysates. (J:107913)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chmp5 Mutation: 16 strains or lines available

References

• Original: J:107913 Shim JH, et al., CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol. 2006 Mar 27;172(7):1045-56
• All: 2 reference(s)