Ret^tm1Cti
Targeted Allele Detail

Summary

• Symbol: Ret^tm1Cti
• Name: ret proto-oncogene; targeted mutation 1, Cristiana Carniti
• MGI ID: MGI:3626295
• Synonyms: Ret^C620R
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1Cti page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107335
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutation: Nucleotide substitutions
• A C620R mutation was inserted into exon 10. RT-PCR confirmed expression of the mutant transcript. (J:107335)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:107335 Carniti C, et al., The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease. Am J Pathol. 2006 Apr;168(4):1262-75
• All: 2 reference(s)