Igh-J^tm1Dim
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Dim
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Diane Mathis
• MGI ID: MGI:3626301
• Synonyms: H¹²¹
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107241
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector containing the mAb 6.121 VHDHJH sequence and a loxP-flanked neomycin resistance cassette was inserted into the locus to replace the JH region. Cre mediated recombination subsequently removed the neomycin cassette upon transmission from male chimeric mice. (J:107241)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

Notes

Targeting took place in ES cells that contain the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells.

References

• Original: J:107241 Huang H, et al., Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3734-9
• All: 1 reference(s)