Nell1^l7R6-6R
Chemically induced Allele Detail

Summary

• Symbol: Nell1^l7R6-6R
• Name: NEL-like 1; 6 Oak Ridge
• MGI ID: MGI:3626314
• Synonyms: l7R6^6R
• Gene: Nell1 Location: Chr7:49625098-50513037 bp, + strand Genetic Position: Chr7, 31.79 cM
• Alliance: Nell1^l7R6-6R page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion converts a codon for cysteine into a premature stop codon, resulting in severe truncation of the predicted protein product and significant reduction in steady-state levels of the transcript. (J:108241)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nell1 Mutation: 57 strains or lines available

References

• Original: J:108241 Desai J, et al., Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
• All: 6 reference(s)