Kcnj8^sltr
Chemically induced Allele Detail

Summary

• Symbol: Kcnj8^sltr
• Name: potassium inwardly-rectifying channel, subfamily J, member 8; solitaire
• MGI ID: MGI:3626349
• Gene: Kcnj8 Location: Chr6:142510563-142517340 bp, - strand Genetic Position: Chr6, 74.31 cM
• Alliance: Kcnj8^sltr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutations: Intragenic deletion, Inversion
• Kcnj8^sltr involves 1 genes/genome features (Kcnj8) View all
• Mutation details: Solitaire mice exhibit the same phenotype as mayday mice, which contain a mutation in Kcnj8. Although they arose in distinct pedigrees, complementation testing indicated that solitaire is allelic with mayday. Sequencing revealed that the solitaire allele contains the same mutation as the mayday allele. The mutation in Kcnj8 consists of a deletion of exon 1 and most of exon 2, due to their replacement by an inverted segment of intron 2. (J:88776, J:126658)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj8 Mutation: 34 strains or lines available

Notes

The mutation was identified as a result of immunocompromise observed in progeny of ENU-mutagenized mice during infection with mouse cytomegalovirus (MCMV). Mice carrying this mutation show higher susceptibility than that observed in susceptible BALB/c mice.

References

• Original: J:105543 Crozat K, et al., Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406
• All: 3 reference(s)