Dnmt3b^tm7Enl
Targeted Allele Detail

Summary

• Symbol: Dnmt3b^tm7Enl
• Name: DNA methyltransferase 3B; targeted mutation 7, En Li
• MGI ID: MGI:3628447
• Synonyms: Dnmt3b^G
• Gene: Dnmt3b Location: Chr2:153491370-153529650 bp, + strand Genetic Position: Chr2, 75.79 cM, cytoband A2-A3
• Alliance: Dnmt3b^tm7Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a D823G substitution. Cre mediated recombination removed a floxed IRES-betageo from the locus. This allele produced protein at levels similar to those of wild-type mice. (J:106540)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3b Mutation: 52 strains or lines available

References

• Original: J:106540 Ueda Y, et al., Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development. 2006 Mar;133(6):1183-92
• All: 2 reference(s)