Ar^tm1(AR)Dmr
Targeted Allele Detail

Summary

• Symbol: Ar^tm1(AR)Dmr
• Name: androgen receptor; targeted mutation 1, Diane M Robins
• MGI ID: MGI:3628485
• Synonyms: 12Q, AR12Q
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1(AR)Dmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108849
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ar^tm1(AR)Dmr expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: Human androgen receptor amino acids 31 to 484 were inserted into the mouse locus. This allele contains 12 glutamine residues in the N terminal. Transient cre expression removed a floxed neo from the recombined locus. RT-PCR demonstrated higher levels of transcript in mutants than wild-type. Western blot showed that protein levels were also somewhat higher. (J:108849)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:108849 Albertelli MA, et al., Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol Endocrinol. 2006 Jun;20(6):1248-60
• All: 6 reference(s)