Gabra2^tm1.1Dias
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm1.1Dias
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1.1, Rebecca Dias
• MGI ID: MGI:3628505
• Synonyms: alpha2H101R
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm1.1Dias page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109259
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was introduced that altered codon 101 from one encoding histidine to one encoding arginine (H101R). A loxP flanked neomycin selection cassette was also inserted into the locus and was subsequently removed via Cre mediated recombination for the final allele. (J:109259)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 36 strains or lines available

References

• Original: J:109259 Dias R, et al., Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J Neurosci. 2005 Nov 16;25(46):10682-8
• All: 4 reference(s)