Slc6a4^{Gt1(IRESBetageo)lLex}
Gene trapped Allele Detail

Summary

• Symbol: Slc6a4^{Gt1(IRESBetageo)lLex}
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; gene trap 1, Lexicon Genetics
• MGI ID: MGI:3628526
• Synonyms: 5-HTT^-
• Gene: Slc6a4 Location: Chr11:76889429-76923166 bp, + strand Genetic Position: Chr11, 46.18 cM
• Alliance: Slc6a4^{Gt1(IRESBetageo)lLex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108880
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a splice acceptor sequence, an internal ribosomal entry site, a selectable colorimetric marker, beta-geo and a polyA sequence was inserted into intron 13 of the locus. RT-PCR confirmed the expression of a fusion transcript in mutant brains, however, the level of expression was significantly lower than in wild-type mice. (J:108880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a4 Mutation: 53 strains or lines available

References

• Original: J:108880 Zhao S, et al., Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience. 2006;140(1):321-34
• All: 1 reference(s)