Tert^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Tert^tm1Rdp
• Name: telomerase reverse transcriptase; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:3628579
• Synonyms: mTert1^-
• Gene: Tert Location: Chr13:73775030-73797962 bp, + strand Genetic Position: Chr13, 40.12 cM
• Alliance: Tert^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1, containing the ATG and encoding the RNA/DNA binding domain, was deleted. Activity of the mutant protein was not detected in the TRAP assay. (J:108914)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tert Mutation: 55 strains or lines available

References

• Original: J:108914 Farazi PA, et al., Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006 May 1;66(9):4766-73
• All: 5 reference(s)