Gata2^tm1Sac
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Sac
• Name: GATA binding protein 2; targeted mutation 1, Sally A Camper
• MGI ID: MGI:3628639
• Synonyms: Gata2^f
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Sac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108963
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo was inserted into intron 4, and a pair of loxP sites: one upstream of the neo and one downstream of exon 5, which encodes the C-terminal zinc finger domain. Expression of Flpe recombinase removed the neo. (J:108963)

Expression

In Mice Carrying this Mutation:	230 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 30 strains or lines available

References

• Original: J:108963 Charles MA, et al., Pituitary-specific gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol. 2006 Jun;20(6):1366-77
• All: 26 reference(s)