Abcb7^tm1Mdf
Targeted Allele Detail

Summary

• Symbol: Abcb7^tm1Mdf
• Name: ATP-binding cassette, sub-family B member 7; targeted mutation 1, Mark D Fleming
• MGI ID: MGI:3628654
• Gene: Abcb7 Location: ChrX:103324263-103457462 bp, - strand Genetic Position: ChrX, 46.58 cM, cytoband C-D
• Alliance: Abcb7^tm1Mdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106838
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the locus to flank exons 9 and 10. Transient cre expression removed a neomycin resistance cassette included in the vector. (J:106838)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcb7 Mutation: 13 strains or lines available

References

• Original: J:106838 Pondarre C, et al., The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet. 2006 Mar 15;15(6):953-64
• All: 5 reference(s)