Nptx2^tm1Mspn
Targeted Allele Detail

Summary

• Symbol: Nptx2^tm1Mspn
• Name: neuronal pentraxin 2; targeted mutation 1, Mark S Perin
• MGI ID: MGI:3628749
• Synonyms: NARP^-, NP2^-
• Gene: Nptx2 Location: Chr5:144482712-144494288 bp, + strand Genetic Position: Chr5, 84.58 cM, cytoband G2
• Alliance: Nptx2^tm1Mspn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1, contining the signal peptide, with a neomycin resistance cassette. Northern blot failed to detect wild-type transcript in mutants. (J:109215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nptx2 Mutation: 24 strains or lines available

Notes

ES cell line was "129/SVJII derived."

References

• Original: J:109215 Bjartmar L, et al., Neuronal pentraxins mediate synaptic refinement in the developing visual system. J Neurosci. 2006 Jun 7;26(23):6269-81
• All: 9 reference(s)