Psmc3ip^tm1Rdco
Targeted Allele Detail

Summary

• Symbol: Psmc3ip^tm1Rdco
• Name: proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein; targeted mutation 1, R Daniel Camerini-Otero
• MGI ID: MGI:3628799
• Synonyms: Hop2^-
• Gene: Psmc3ip Location: Chr11:100982649-100986262 bp, - strand Genetic Position: Chr11, 64.19 cM, cytoband D
• Alliance: Psmc3ip^tm1Rdco page

The number of meiotic double stranded breaks is reduced in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc and Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco females

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109004
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the first three exons and part of the 5' UTR with a neomycin resistance gene. Western blot analysis of mutant testes extracts did not indicate presence of protein. (J:109004)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc3ip Mutation: 7 strains or lines available

References

• Original: J:109004 Petukhova GV, et al., The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis. Dev Cell. 2003 Dec;5(6):927-36
• All: 11 reference(s)