Ddo^tm1Rdl
Targeted Allele Detail

Summary

• Symbol: Ddo^tm1Rdl
• Name: D-aspartate oxidase; targeted mutation 1, Roberto Di Lauro
• MGI ID: MGI:3628810
• Synonyms: Ddo^-
• Gene: Ddo Location: Chr10:40506007-40557843 bp, + strand Genetic Position: Chr10, 22.0 cM, cytoband B1
• Alliance: Ddo^tm1Rdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109184
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-neo cassette replaced exons 0-2. Western blot analysis of kidney, brain and spleen confirmed that protein was absent in mutants. (J:109184)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddo Mutation: 15 strains or lines available

References

• Original: J:109184 Errico F, et al., A physiological mechanism to regulate d-aspartic acid and NMDA levels in mammals revealed by d-aspartate oxidase deficient mice. Gene. 2006 Jun 7;374:50-7
• All: 8 reference(s)