Nrgn^tm1Sut
Targeted Allele Detail

Summary

• Symbol: Nrgn^tm1Sut
• Name: neurogranin; targeted mutation 1, J Gregor Sutcliffe
• MGI ID: MGI:3628817
• Synonyms: RC3-beta-Gal
• Gene: Nrgn Location: Chr9:37455789-37464041 bp, - strand Genetic Position: Chr9, 20.78 cM
• Alliance: Nrgn^tm1Sut page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109224
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert lacZ into exon 2 in frame such that a fusion protein would be expressed under the control of the endogenous promoter. The resulting protein consists of the first 30 residues of neurogranin followed by beta-gal sequence. The fusion protein does not contain the target of protein kinase C phosphorylation (Ser36) or residues required for binding to calmodulin. (J:109224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrgn Mutation: 8 strains or lines available

References

• Original: J:109224 Krucker T, et al., Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci. 2002 Jul 1;22(13):5525-35
• All: 1 reference(s)