Pdpk1^tm1Maka
Targeted Allele Detail

Summary

• Symbol: Pdpk1^tm1Maka
• Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Masato Kasuga
• MGI ID: MGI:3628819
• Synonyms: betaPdk1^-, Pdk1^flox, Pdk1^tm1Maka
• Gene: Pdpk1 Location: Chr17:24292654-24369898 bp, - strand Genetic Position: Chr17, 12.23 cM, cytoband A3.3
• Alliance: Pdpk1^tm1Maka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109359
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 3 and 4. Transient cre expression removed a floxed neo that was inserted into the locus. (J:109359)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpk1 Mutation: 138 strains or lines available

References

• Original: J:109359 Inoue H, et al., Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab. 2006 Apr;3(4):267-75
• All: 24 reference(s)