Flt3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Flt3^m1Btlr
• Name: FMS-like tyrosine kinase 3; mutation 1, Bruce Beutler
• MGI ID: MGI:3628823
• Synonyms: Flt3^wmfl, warmflash
• Gene: Flt3 Location: Chr5:147267551-147337299 bp, - strand Genetic Position: Chr5, 86.88 cM, cytoband G3
• Alliance: Flt3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered in a screen of G3 progeny of an ENU mutagenized mouse for susceptibility to infection by mouse cytomegalovirus (MCMV), comprises a G to A transversion at nucleotide position 33572 of the genomic sequence (GenBank genomic region NC_000072 for linear genomic sequence of Flt3). This destroys the donor splice site of intron 9, resulting in the use of an alternative donor splice site six nucleotides away, within exon 9, and thus causing deletion of the last two amino acids (tyrosine and serine) encoded by exon 9. (J:88776, J:159599)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flt3 Mutation: 90 strains or lines available

Notes

The mutation was identified as a result of immunocompromise observed in progeny of ENU-mutagenized mice during infection with mouse cytomegalovirus (MCMV).

References

• Original: J:105543 Crozat K, et al., Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406
• All: 4 reference(s)