Stx1a^tm1Tfuj
Targeted Allele Detail

Summary

• Symbol: Stx1a^tm1Tfuj
• Name: syntaxin 1A (brain); targeted mutation 1, Tomonori Fujiwara
• MGI ID: MGI:3629049
• Synonyms: Synt1A^-
• Gene: Stx1a Location: Chr5:135052336-135079954 bp, + strand Genetic Position: Chr5, 74.95 cM
• Alliance: Stx1a^tm1Tfuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109042
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace sequence encompassing exon 9 and part of exon 10, sequence encoding the H3 and transmembrane domains, with a neomycin resistance gene. Northern blot and Western blot analyses confirmed the absence of transcript and protein, respectively, from mutants. (J:109042)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Stx1a Mutation: 26 strains or lines available

References

• Original: J:109042 Fujiwara T, et al., Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. J Neurosci. 2006 May 24;26(21):5767-76
• All: 10 reference(s)