Lig3^tm1Czhu
Targeted Allele Detail

Summary

• Symbol: Lig3^tm1Czhu
• Name: ligase III, DNA, ATP-dependent; targeted mutation 1, Chengming Zhu
• MGI ID: MGI:3629052
• Synonyms: LIG3^-
• Gene: Lig3 Location: Chr11:82671977-82695100 bp, + strand Genetic Position: Chr11, 50.23 cM, cytoband B5
• Alliance: Lig3^tm1Czhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109063
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 through 13 were replaced with a neomycin resistance gene in reverse orientation. Western blot confirmed absence of protein in mutants. (J:109063)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig3 Mutation: 41 strains or lines available

References

• Original: J:109063 Puebla-Osorio N, et al., Early embryonic lethality due to targeted inactivation of DNA ligase III. Mol Cell Biol. 2006 May;26(10):3935-41
• All: 1 reference(s)