Ecel1^tm1Jroh
Targeted Allele Detail

Summary

• Symbol: Ecel1^tm1Jroh
• Name: endothelin converting enzyme-like 1; targeted mutation 1, Jack Rohrer
• MGI ID: MGI:3629091
• Synonyms: XCE^-
• Gene: Ecel1 Location: Chr1:87075377-87084243 bp, - strand Genetic Position: Chr1, 44.06 cM, cytoband C5
• Alliance: Ecel1^tm1Jroh page

Congenital atelectasis in Ecel1^tm1Jroh/Ecel1^tm1Jroh lungs

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56300
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the zinc-binding motif and the next two downstream exons were replaced with a neomycin resistance gene. RT-PCR analysis confirmed absence of transcript in mutant brain samples. (J:56300)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ecel1 Mutation: 41 strains or lines available

References

• Original: J:56300 Schweizer A, et al., Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. J Biol Chem. 1999 Jul 16;274(29):20450-6
• All: 1 reference(s)