Orgwt4^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Orgwt4^CAST/EiJ
• Name: organ weight 4; CAST/EiJ
• MGI ID: MGI:3629146
• QTL: Orgwt4 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:108423

Linkage analysis was performed on 421 animals from a M16i x (M16i x CAST/EiJ)F1 backcross to identify QTL associated with body weight and body composition. 92 microsatellite markers were used for the genome scan. Parental strain M16i exhibits increased growth rate, body weight, and mild obesity compared to parental strain CAST/EiJ. All identified QTL appear to participate in epistatic interactions contributing a low but detectable percentage of the phenotypic variance.

Linkage to body weight at 3 weeksof age mapped to 72 cM on mouse Chromosome 1 (LOD=5.74 near D1Mit140) and is named Gwth1 (growth traits 1). The confidence interval spans 57 cM - 86 cM. Gwth1 participates in epistatic interaction with the locus on chromosome 18 at D18Nds1 (Gwth7) affecting fatness and body weight in older mice. Gwth1 is also linked to kidney weight with LOD=6.89.

Linkage to body weight mapped to several peaks on mouse Chromosome 2 and is collectively called Gwth2 (growth traits 2). The confidence interval of Gwth2 spans approximately 36 cM - 85 and is linked to body weight at 6, 9, and 12 (highest LOD=13.65). Linkage to gonadal fat pad weight mapped to 77 cM (LOD=17-20) and is named Fatpad1. This locus explains 18% of the fat trait variance and coincides with a QTL peak for body weight at 9 and 12 weeks. Linkage to liver weight mapped to 64 cM with LOD=17.61. This locus is named Orgwt1 (organ weight 1). The confidence interval of Orgwt1 spans 59 cM - 69 cM. Linkage to spleen weight and kidney weight occurred at 73 cM (Orgwt2; LOD=3.97) and 86 cM (Orgwt3; LOD=8.49), respectively.

Linkage to kidney weight was detected at 65 cM on mouse Chromosome 3 (LOD=3.54). The confidence interval spans 47 cM - 75 cM. This locus is named Orgwt4 (organ weight 4).

Linkage to body weight at 12 days of age mapped to 17 cM on mouse Chromosome 4 (LOD=3.41). This locus is named Gwth3 (growth traits 3). The confidence interval spans 11 cM - 41 cM. Linkage to spleen weight mapped to 49 cM with LOD=6.51. This locus is named Orgwt5 (organ weight 5).

Linkage to combined fat pad weight mapped to 31 cM on mouse Chromosome 5 with LOD=3.63. This locus is named Fatpad2. The confidence interval of Fatpad2 spans 12 cM - 28 cM.

Linkage to spleen weight mapped to 28 cM on mouse Chromosome 9 with LOD=7.87. This locus is named Orgwt6 (organ weight 6). The confidence interval spans 17 cM - 40 cM.

Linkage to spleen weight mapped to 29 cM on mouse Chromosome 10 with LOD=3.54. This locus is named Orgwt7 (organ weight 7). The confidence interval spans 20cM - 40 cM.

On mouse Chromosome 11, linkage to liver weight and body weight at 12 weeks of age mapped to 23 cM with LOD=4.14. This locus is named Gwth4 (growth traits 4). The confidence interval spans 7 cM - 52 cM.

Linkage to fat traits mapped to 34 cM- 41 cM on mouse Chromosome 13 (highest LOD=4.6) and is named Fatpad3. The confidence interval spans approximately 21 cM - 47 cM. CAST/EiJ-derived alleles at Fatpad3 confer increased fat traits (gonadal, subcutaneous, and combined). This locus explains 4% of the fat trait variance.

Linkage to subcutaneous fat pad weight mapped to 30 cM on mouse Chromosome 14 with LOD=3.7. This locus is named Fatpad4. The confidence interval of Fatpad4 spans 16 cM - 43 cM.

On mouse Chromosome 15, linkage to body weightat 9 and 12 weeks of age mapped to an interval from 42 cM - 58 cM (highest LOD=4.16). This locus is named Gwth 5 (growth traits 5). The confidence interval spans approximately 32 cM - 62 cM. Linkage to all fat pad traits (gonadal, subcutaneous, and combined) mapped to 35 cM (highest LOD=4.54). This locus is named Fatpad5. Linkage to gondal and combined fat pad weights mapped to 24 cM (highest LOD= 3.63). This locus is named Fatpad6.

Linkage to gonadal fat pad weight mapped to 22 cM on mouse Chromosome 17with LOD=3.32. This locus is named Fatpad7.

On mouse Chromosome 18, linkage to body weight at 12 days of age mapped to 22 cM with LOD=3.34. This locus is named Gwth6 (growth traits 6). The confidence interval spans 6 cM - 72 cM. A second locus named Gwth7 (growth traits 7) mapped to 45 cM - 48 cM. Gwth7 is linked to body weight at 12 days and 3 weeks of age with maximum LOD=4.71 near D18Nds1. The confidence interval of Gwth7 spans 13 cM - 65 cM. This locus participates in epistatic interaction with Gwth1 on chromosome 1 and affects fatness and body weight in older mice. A locus named Orgwt8 (organ weight 8) at 73 cM shows linkage to kidney weight with LOD=6.95. The confidence interval spans 61 cM - 73 cM.

References

• Original: J:108423 Yi N, et al., Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice. Genet Res. 2006 Feb;87(1):45-60
• All: 1 reference(s)