Xiap^tm1Vdr
Targeted Allele Detail

Summary

• Symbol: Xiap^tm1Vdr
• Name: X-linked inhibitor of apoptosis; targeted mutation 1, J E Visvader
• MGI ID: MGI:3629213
• Synonyms: Xiap^-
• Gene: Xiap Location: ChrX:41148556-41198533 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
• Alliance: Xiap^tm1Vdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109330
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1 and 2 with a neomycin resistance gene. The deleted sequence contains the initiation codon, the first two BIR domains and the third BIR domain. Western blot showed absence of protein in mutants. (J:109330)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xiap Mutation: 37 strains or lines available

References

• Original: J:109330 Olayioye MA, et al., XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland. Cell Death Differ. 2005 Jan;12(1):87-90
• All: 13 reference(s)