Fgf10^{Tg(Myl3-lacZ)24Buck}
Transgenic Allele Detail

Summary

• Symbol: Fgf10^{Tg(Myl3-lacZ)24Buck}
• Name: fibroblast growth factor 10; transgene insertion 24, Margaret E Buckingham
• MGI ID: MGI:3629660
• Synonyms: Fgf10^-, Fgf10^lacZ, Fgf10^{Mlc1v-nLacZ-v24}, Fgf10^mlcv, Fgf10^{Mlcv-nlacZ-v24}, Mlc1v-nlacZ-24
• Gene: Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
• Alliance: Fgf10^{Tg(Myl3-lacZ)24Buck} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains 757 bp upstream of the transcriptional start site, the 5' UTR and the first 33 codons of the mouse myosin light polypeptide 3 gene upstream of nlacZ. The promoter contains a 34 bp deletion at -150 relative to the transcription start site. Two to three copies of the transgene integrated 114 kb upstream of the locus in a head-to-tail array. Expression of the transgene is in a highly similar pattern to that of Fgf10 in the embryo. Whole mount in-situ analysis detected decreased expression of the endogenous gene in homozygous embryos indicating this is a hypomorphic allele. (J:71788, J:98521)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf10 Mutation: 33 strains or lines available

References

• Original: J:71788 Kelly RG, et al., The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell. 2001 Sep;1(3):435-440
• All: 45 reference(s)