Slc6a4^tm1Grch
Targeted Allele Detail

Summary

• Symbol: Slc6a4^tm1Grch
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Jay A Gingrich
• MGI ID: MGI:3629666
• Synonyms: 5-htt^-
• Gene: Slc6a4 Location: Chr11:76889429-76923166 bp, + strand Genetic Position: Chr11, 46.18 cM
• Alliance: Slc6a4^tm1Grch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109542
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon of the transporter-coding region was partially deleted and replaced with a neomycin resistance cassette. (J:109542)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a4 Mutation: 53 strains or lines available

References

• Original: J:109542 Lira A, et al., Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry. 2003 Nov 15;54(10):960-71
• All: 4 reference(s)