Pcsk1^N222D
Chemically induced Allele Detail

Summary

• Symbol: Pcsk1^N222D
• Name: proprotein convertase subtilisin/kexin type 1; N222D
• MGI ID: MGI:3629669
• Synonyms: Pc1^N222D
• Gene: Pcsk1 Location: Chr13:75237945-75282980 bp, + strand Genetic Position: Chr13, 40.63 cM, cytoband C2
• Alliance: Pcsk1^N222D page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• An A to G transition resulted in an asparagines to aspartic acid at codon 222. (J:109531)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk1 Mutation: 50 strains or lines available

References

• Original: J:109531 Lloyd DJ, et al., Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum Mol Genet. 2006 Jun 1;15(11):1884-93
• All: 2 reference(s)