Tg(Myh6-IGF1R)7Jmcm
Transgene Detail

Summary

• Symbol: Tg(Myh6-IGF1R)7Jmcm
• Name: transgene insertion 7, Julie R McMullen
• MGI ID: MGI:3630255
• Synonyms: MHCalpha-IgfR
• Transgene: Tg(Myh6-IGF1R)7Jmcm Location: unknown
• Alliance: Tg(Myh6-IGF1R)7Jmcm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-IGF1R)7Jmcm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1R (3480)

  Igf1r

  (MGI:96433)

• Mutation details: This transgene consists of the mouse alpha myosin heavy chain (Myh6) promoter driving the expression of the human IGF1R cDNA in the heart. IGF1R ligand binding assays indicate that line 7 shows a 20-fold increase in expression of IGF1R in cardiac membrane fractions. (J:87944)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87944 McMullen JR, et al., The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem. 2004 Feb 6;279(6):4782-93
• All: 4 reference(s)