Gsc2^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Gsc2^tm1Bhr
• Name: goosecoid homebox 2; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3630276
• Gene: Gsc2 Location: Chr16:17730978-17732891 bp, - strand Genetic Position: Chr16, 11.1 cM
• Alliance: Gsc2^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50873
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb genomic fragment that contains all three coding exons was deleted and replaced with a neomycin selection cassette. Southern blot analysis confirmed that the gene coding region was deleted. (J:50873)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsc2 Mutation: 13 strains or lines available

References

• Original: J:50873 Wakamiya M, et al., Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes. Hum Mol Genet. 1998 Nov;7(12):1835-40
• All: 1 reference(s)