Tg(ACTA1-IGF1)1Rjs
Transgene Detail

Summary

• Symbol: Tg(ACTA1-IGF1)1Rjs
• Name: transgene insertion 1, Robert J Schwartz
• MGI ID: MGI:3630335
• Synonyms: SIS2, SK733 IGF-1 3'-SK
• Transgene: Tg(ACTA1-IGF1)1Rjs Location: unknown
• Alliance: Tg(ACTA1-IGF1)1Rjs page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-IGF1)1Rjs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1 (3479)

  Igf1	(MGI:96432)

• Mutation details: The proximal promoter region, together with the first intron and 1.8 kilobases of 3'-noncoding flanking sequence of the avian skeletal alpha-actin gene directs the expression of human insulin-like growth factor 1 (IGF1). Transgenic mice harbor a single copy of the transgene that is expressed in striated muscle and is more abundant in skeletal muscle than in the heart. IGF1 concentration is elevated 47-fold in skeletal muscle. (J:25522)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:25522 Coleman ME, et al., Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem. 1995 May 19;270(20):12109-16
• All: 7 reference(s)