Tg(Myh6-IGF1)34Pia
Transgene Detail

Summary

• Symbol: Tg(Myh6-IGF1)34Pia
• Name: transgene insertion 34, Piero Anversa
• MGI ID: MGI:3630343
• Synonyms: Igf⁺, IGF1 TGM
• Transgene: Tg(Myh6-IGF1)34Pia Location: unknown
• Alliance: Tg(Myh6-IGF1)34Pia page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-IGF1)34Pia expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1 (3479)

  Igf1	(MGI:96432)

• Mutation details: This transgene consists of the human insulin-like growth factor 1B cDNA under the control of the rat alpha-myosin heavy chain promoter. IGF1 mRNA was not detectable in the fetal heart at the end of gestation but is present at modest levels at 1 day after birth and increased progressively with postnatal maturation, reaching a peak at 75 days. IGF1 is exclusively expressed in the heart. (J:35215)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:35215 Reiss K, et al., Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8630-5
• All: 12 reference(s)