Tg(Myh6-Akt1*T308D*S473D)1Siz
Transgene Detail

Summary

• Symbol: Tg(Myh6-Akt1*T308D*S473D)1Siz
• Name: transgene insertion 1, Seigo Izumo
• MGI ID: MGI:3639116
• Synonyms: caAkt
• Transgene: Tg(Myh6-Akt1*T308D*S473D)1Siz Location: unknown
• Alliance: Tg(Myh6-Akt1*T308D*S473D)1Siz page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains a constitutively active mouse Akt1, in which critical residues (T308D/S473D) for activation of Akt1 are replaced by negatively charged amino acids, under the control of the mouse alpha-myosin heavy chain. There is about 400 times more transgene product than endogenous Akt1 in cardiac tissue. (J:75780)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75780 Shioi T, et al., Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol. 2002 Apr;22(8):2799-809
• All: 3 reference(s)