Tg(Myh6-Akt1)564Anr
Transgene Detail

Summary

• Symbol: Tg(Myh6-Akt1)564Anr
• Name: transgene insertion 564, Anthony Rosenzweig
• MGI ID: MGI:3639127
• Synonyms: TG564
• Transgene: Tg(Myh6-Akt1)564Anr Location: unknown
• Alliance: Tg(Myh6-Akt1)564Anr page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expresses a constitutively active mutant of Akt1 (the Akt1 cDNA contains a Src myristoylation signal) under the control of the mouse alpha-myosin heavy chain promoter. The transgene is expressed in the heart and at low levels in the lung but not in kidney or skeletal muscle. (J:77257)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77257 Matsui T, et al., Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002 Jun 21;277(25):22896-901
• All: 3 reference(s)