Errfi1^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Errfi1^tm1Kln
• Name: ERBB receptor feedback inhibitor 1; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:3639295
• Synonyms: Errfi1^-, Mig6^-
• Gene: Errfi1 Location: Chr4:150938376-150953349 bp, + strand Genetic Position: Chr4, 81.5 cM, cytoband E1
• Alliance: Errfi1^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109556
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the entire coding locus. Western blot failed to detect protein in mutant liver and lung lysates. (J:109556)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Errfi1^tm1Kln

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Errfi1 Mutation: 18 strains or lines available

References

• Original: J:109556 Ferby I, et al., Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med. 2006 May;12(5):568-73
• All: 3 reference(s)