Ascl1^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Ascl1^tm1Cbm
• Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:3639318
• Synonyms: Mash1^GFP
• Gene: Ascl1 Location: Chr10:87326681-87329522 bp, - strand Genetic Position: Chr10, 43.64 cM
• Alliance: Ascl1^tm1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109482
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Gap43-GFP cDNA and a floxed neomycin resistance gene replaced exon 1 of the locus. Cre mediated recombination removed the floxed neo. Expression in mutants was detected only in the progenitor zone. (J:109482)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl1 Mutation: 28 strains or lines available

References

• Original: J:109482 Wildner H, et al., dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development. 2006 Jun;133(11):2105-13
• All: 6 reference(s)