Hpn^tm1Qwu
Targeted Allele Detail

Summary

• Symbol: Hpn^tm1Qwu
• Name: hepsin; targeted mutation 1, Qingyu Wu
• MGI ID: MGI:3639336
• Synonyms: Tmprss1^-
• Gene: Hpn Location: Chr7:30798150-30814715 bp, - strand Genetic Position: Chr7, 19.3 cM
• Alliance: Hpn^tm1Qwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45393
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-8, which encode the conserved activation site and most of the catalytic domain, were deleted and replaced with a neomycin selection cassette. Northern blot analysis of total liver RNA derived from mutant mice demonstrated that no detectable transcript is expressed from this allele. (J:45393)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hpn Mutation: 22 strains or lines available

References

• Original: J:45393 Wu Q, et al., Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. J Clin Invest. 1998 Jan 15;101(2):321-6
• All: 6 reference(s)