Cd4^tm1Jrp
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1Jrp
• Name: CD4 antigen; targeted mutation 1, Jane R Parnes
• MGI ID: MGI:3639344
• Synonyms: Cd4^low
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1Jrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45168
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 10, 3' to the coding sequences of the gene. This allele expresses a twofold lower level of the encoded protein in the thymus and thus behaves as a hypomorph. (J:45168)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cd4^tm1Jrp/Cd4^tm1Jrp	either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp
cx2	Cd4^tm1Jrp/Cd4^tm1Jrp Tg(TcrAND)53Hed/0	either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)
cx3	B2m^tm1Jae/B2m^tm1Jae Cd4^tm1Jrp/Cd4^tm1Jrp	involves: 129S2/SvPas * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2	cx3
show or hide all annotated terms
endocrine/exocrine glands		√
thymus hyperplasia		√
hematopoietic system	√	√	√
thymus hyperplasia		√
abnormal T cell differentiation	√
abnormal T cell number		√
decreased double-positive T cell number	√
decreased CD4-positive, alpha-beta T cell number	√
increased CD8-positive, alpha-beta T cell number	√		√
immune system	√	√	√
thymus hyperplasia		√
abnormal T cell differentiation	√
decreased double-positive T cell number	√
abnormal T cell number		√
decreased CD4-positive, alpha-beta T cell number	√
increased CD8-positive, alpha-beta T cell number	√		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 84 strains or lines available

References

• Original: J:45168 Frank GD, et al., The level of CD4 surface protein influences T cell selection in the thymus. J Immunol. 1998 Jan 15;160(2):634-42
• All: 1 reference(s)