Kif1a^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Kif1a^tm1Noh
• Name: kinesin family member 1A; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:3639347
• Gene: Kif1a Location: Chr1:92943186-93029673 bp, - strand Genetic Position: Chr1, 46.74 cM, cytoband E1-E2
• Alliance: Kif1a^tm1Noh page

Gross appearance and small size of Kif1a^tm1Noh/Kif1a^tm1Noh mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47170
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ/neomycin selection cassette was inserted in-frame into the first coding exon of the gene. Immunoblot analysis of protein extracted from total brain homogenate demonstrated that no endogenous protein was expressed from this allele. Expression of beta-galactosidase was not reported. (J:47170)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif1a Mutation: 95 strains or lines available

References

• Original: J:47170 Yonekawa Y, et al., Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J Cell Biol. 1998 Apr 20;141(2):431-41
• All: 2 reference(s)